- multiplayer 
Iron Chef America: Supreme Cuisine is a video game released for Nintendo DS on November 18, 2008, and for the Nintendo Wii one week later. It is based on the television series Iron Chef America and developed by Black Lantern Studios, published by Des ...
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- Single player
Harvest Moon DS: Island of Happiness (牧場物語 キミと育つ島, Bokujō Monogatari: Kimi to Sodatsu Shima?, lit. Farm Story: The Island Grows With You) is a farm simulation video game published and develope ...
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- Nintendo Wi-Fi Connection
Rune Factory: A Fantasy Harvest Moon (ルーンファクトリー -新牧場物語-, Rūn Fakutorī -Shin Bokujō Monogatari-?, literally "Rune Factory: A New Farm Story") is a simulation/role-playing v ...
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MySims Kingdom is a video game developed by EA Redwood Shores and published by Electronic Arts as a spin-off to Maxis' The Sims franchise for the Nintendo DS and Wii in 2008. MySims Kingdom is a follow-up to MySims, which it was released in 2007 and ...
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Rune Factory 2: A Fantasy Harvest Moon, known as Rune Factory 2 (ルーンファクトリー2, Rūn Fakutorī 2?) in Japan, is a simulation/role-playing video game developed by Neverland Co.. It was published in Japan, ...
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- Single player
Hamsterz Life is a hamster simulation video game released by Ubisoft for the Nintendo DS. Hamsterz Life is also known as Love ♥ Hamster or Love Love Hamster in Japan. ...
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Purr Pals is a pet simulation game in which the player takes care of a kitten. It is Crave Entertainment's answer to Nintendo's Nintendogs and is sponsored by Purina. ...
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Spore Hero Arena is an American Nintendo DS spin-off of Spore Hero which was released in North America on October 6, 2009, and worldwide on October 8. This game is the second Spore game for the Nintendo DS, and improved from its predecessor with its ...
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Digimon World Championship (デジモンチャンピオンシップ Dejimon Chanpionshippu) is a life simulation game and the fourth Digimon game for the Nintendo DS. ...
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The Sims 2: Pets is the fourth expansion pack in The Sims 2 series of games published by Electronic Arts. It was also sold as a stand-alone game for several consoles. The Sims 2: Pets was officially announced on July 26, 2006 and released on October ...
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Family Park Tycoon is a business simulation video game for the Nintendo DS developed by VIS Games and Entertainment, a division of Visual Imagination Games and Software, and published by Astragon. Game play focuses on amusement park management. ...
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Tigerz is a videogame in the Petz series, released by Ubisoft in February 2008 for the Nintendo DS. It was released after Petz 5, and is therefore part of the second Petz series. Players take on the roles of Enzo and Anna, two young animal trainers w ...
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Trauma Center: Under the Knife 2 (救急救命 カドゥケウス2, Kyūkyū Kyūmei Kadukeusu 2?, lit. "Medical Emergency: Caduceus 2") is a simulation game developed for the Nintendo DS and the third in the Traum ...
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Gardening Mama (ガーデニングママ Gādeningu Mama) is a gardening simulation-styled minigame compilation video game for the Nintendo DS and iOS. It is a spin-off from the Cooking Mama series. ...
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- Single player
Neon Genesis Evangelion: Ayanami Raising Project (新世紀エヴァンゲリオン 綾波育成計画, Shin Seiki Evangelion: Ayanami Ikusei Keikaku?) is a simulation game created by Gainax and BROC ...
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- multiplayer Single player
Spore Creatures is the Nintendo DS spin-off of Spore, developed by Foundation 9, in which a player controls and evolves a creature of their creation and a drama adventure game. ...
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