- Single player 
Paint By DS is a painting simulator developed by Ertain for the Nintendo DS. The game challenges players to recreate classic artworks with the DS stylus. It allows players to recreate pieces from artists such as Van Gogh. Players can mix oil-based an ...
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Family Park Tycoon is a business simulation video game for the Nintendo DS developed by VIS Games and Entertainment, a division of Visual Imagination Games and Software, and published by Astragon. Game play focuses on amusement park management. ...
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- Single player
Fish Tycoon is a casual game created and developed by Last Day of Work. One of the top-selling downloadable games of 2004, 2005, and 2006,Fish Tycoon was later ported to cell phone, retail, and Nintendo DS. ...
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- Single player
Zoo Tycoon DS is the Nintendo DS version of the popular business simulation game, Zoo Tycoon. A sequel to the game, titled Zoo Tycoon 2 DS, was released three years later in 2008. ...
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Gardening Mama (ガーデニングママ Gādeningu Mama) is a gardening simulation-styled minigame compilation video game for the Nintendo DS and iOS. It is a spin-off from the Cooking Mama series. ...
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Bratz Ponyz 2 is a simulation video game released for the Nintendo DS in the PAL region and in North America on June 22, 2008 and July 30, 2008, respectively. The game is part of the Bratz Petz series and a sequel to Bratz Ponyz. The game is almost i ...
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The Sims 2: Pets is the fourth expansion pack in The Sims 2 series of games published by Electronic Arts. It was also sold as a stand-alone game for several consoles. The Sims 2: Pets was officially announced on July 26, 2006 and released on October ...
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- Wireless Multi-player
Rune Factory 3 (ルーンファクトリー3, Rūn Fakutorī 3?) is a simulation/role-playing video game developed by Neverland Co. and published in Japan by Marvelous Entertainment for the Nintendo DS handheld console. ...
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Pet Pals: Animal Doctor is a video game in which the player is a veterinarian, and must take care of many animals brought to their clinic. It was created by Legacy Interactive. It is rated E10+ by the American Entertainment Software Rating Board. ...
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Babysitting Mania is a simulation-style, time-management game developed by Gogii Games and available for Microsoft Windows and the Nintendo DS. The game allows the player to babysit many virtual children while cleaning the house and managing parties ...
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- Single player
Harvest Moon DS: Island of Happiness (牧場物語 キミと育つ島, Bokujō Monogatari: Kimi to Sodatsu Shima?, lit. Farm Story: The Island Grows With You) is a farm simulation video game published and develope ...
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Monster Tale is a Nintendo DS platformer and virtual pet game developed by DreamRift and published by Majesco in 2011. It was only released in North America. It follows the story of a young girl, named Ellie, and her adventures in Monster World with ...
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- Single player
Hamsterz Life is a hamster simulation video game released by Ubisoft for the Nintendo DS. Hamsterz Life is also known as Love ♥ Hamster or Love Love Hamster in Japan. ...
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- Single player
Cooking Mama (クッキング ママ, Kukkingu Mama?) is a cookery simulation-styled minigame compilation video game for the Nintendo DS and iOS developed by Office Create and published by Taito, Majesco, and 505 Games. It was aw ...
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- multiplayer Single player
Spore Creatures is the Nintendo DS spin-off of Spore, developed by Foundation 9, in which a player controls and evolves a creature of their creation and a drama adventure game. ...
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Let's Play Mums is a party game for kids developed by ZigZag Island and published in 2008 by Deep Silver for the Nintendo DS. ...
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